Dr. Dong is interested in studying the cellular and molecular mechanisms underlying immune tolerance and immune responses, and hopes that his research will lead to new approaches of modulating the immune system in a variety of immune diseases and cancers. The research conducted at the Dong Lab includes:

1. T lymphocyte differentiation and function

2. Cytokine function and signaling in inflammation

3. Immune tolerance and tumor immunity.

2009American Association of Immunologists-BD Biosciences Investigator Award foroutstanding, early-career research contributions to the field of immunology

2011Fellow, American Association for Advancement in Science

2014Highly Cited Researcher, Thomson Reuters

2015Highly Cited Researcher, Thomson Reuters

2016Keynote speaker,2016 Keystone Symposium on T Follicular Helper Cells and Germinal Centers

2016Highly Cited Researcher, Thomson Reuters

2017Highly Cited Researcher, Clarivate Analytics

2018Highly Cited Researcher, Clarivate Analytics

2018Fountain Valley Investigator of Life Sciences (FViL)

2019Dr. Tsai-Fan Yu Foundation Legacy Award, Society of Chinese Bioscientists in America

20192019 International Cytokine and Interferon Society-BioLegend William E. Paul Award

2019Highly Cited Researcher, Web of Sciences

2019Wu Jieping Medicine Prize- Innovation Award in Medicine and Pharmacy

2019Member, Chinese Academy of Sciences

2019The 20^thWu Jieping- Paul Janssen Medical and Pharmaceutical Award

2020Sun Simiao Prize for Outstanding Contributions in Cancer Research and Treatment, Bangcuidao Society for Cancer Research

2020Outstanding Contribution Award, Department of Basic Medical Sciences, Tsinghua University School of Medicine

2020Highly Cited Researcher, Clarivate Analytics

2020 Fellow, Chinese Academy of Medical Sciences

Publications (cited >31000 times, H-index 86)

1.Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R. I.,Wang, Y., Hood, L., Tian, Q. andDong, C.A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 (2005) Nature Immunology 6：1133-1141

2.Nurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y.-H., Watowich, S. S., Jetten, A. M., Tian, Q. andDong, C.Generation of follicular helper T cells is mediated by IL-21 but independent of TH1, TH2 or TH17 lineages.(2008) Immunity 29：138-149

3.Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka,S., Matskevitch, T. D., Wang, Y.-H. andDong, C.Bcl6 mediates the development of T follicular helper cells (2009)Science325：1001-1005.

4.Liu, X., Chen, X., Zhong, B., Wang, A., Wang, X., Chu, F., Nurieva, R. I., Yan, X., Chen, P., van der Flier, L. G., Nakatsukasa, H., Neelapu, S. S., Chen, W., Clevers, H., Tian, Q., Qi, H., Wei, L. andDong, C.Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development (2014) Nature 507：513-518

5.Ding, X., Wang, A., Ma, X., Demarque, M., Jin, W., Xin, H., Dejean, A. andDong, C.Protein SUMOylation is required for regulatory T cell expansion and function. (2016) Cell Reports. 16:1055-1066.

6.Fu, W., Liu, X., Lin, X., Feng, H., Sun, L., Li, S., Chen, H., Tang, H., Lu, L., Jin, W. andDong, C.Deficiency in T follicular regulatory cells promotes autoimmunity. (2018) Journal of Experimental Medicine. 215:815-825.

7.Jiang, Y., Liu, Y., Lu, H., Sun, S.-C., Jin, W., Wang, X. andDong, C.Epigenetic activation during T helper 17 (Th17) cell differentiation is mediated by Tripartite motif containing 28. (2018) Nature Communications. 9:1424.

8.Li, J., Lee, Y., Li, Y., Jiang, Y., Lu, H., Zang, W., Zhao, X., Liu, L., Chen, Y., Tan, H., Yang, Z., Zhang, M. Q., Mak, T. W., Ni, L. andDong, C.Co-inhibitory molecule B7 superfamily member 1 expressed by tumor-infiltrating myeloid cells induces dysfunction of anti-tumor CD8+ T cells (2018) Immunity 48: 773-786

9.Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. andDong, C.An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation(2018)Immunity 48：787-798

10.Liu, X., Wang, Y., Lu, H., Li, J., Yan, X., Xiao, M., Hao, J., Hoang, O. N., Khong, H., Chen, T., Huang, R., Wu, J., Zhao, Q., Wu, Q., Xu, S., Wang, X., Jin, W., Yu, S., Wang, Y., Wei, L., Wang, A., Zhong, B., Ni, L., Liu, X., Nurieva, R., Ye, L., Tian, Q., Bian, X.-W. andDong, C.Genome-wide analysis identifies Nr4a1 as a key mediator of T cell dysfunction (2019) Nature 567：525-529

11.Su, Y., Huang, J., Zhao, X., Lu, H., Wang, W., Yang, X. O., Shi, Y., Wang, X., Lai, Y. andDong, C.Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation (2019) Science Immunology 4(36).

12.Xu, W., Zhao, X., Wang, X., Feng, H., Gou, M., Jin, W., Wang, X., Liu, X. andDong C.The transcription factor Tox2 drives T follicular helper cell development via regulating chromatin accessibility (2019) Immunity 51: 826-839

13.Wang, X., Ni, L., Wan, S., Zhao, X., Ding, X., Dejean, A. andDong, C.Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. (2020) Immunity. 52:328-341.

14.Ni, L., Ye, F., Cheng, M.-L., Feng, Y., Deng, Y.-Q., Zhao, H., Wei, P., Ge, J., Gou, M., Li, X., Sun, L., Cao, T., Wang, P., Zhou, C., Zhang, R., Liang, P., Guo, H., Wang, X., Qin, C.-F., Chen, F. andDong, C.Detection of SARS-CoV-2-specific humoral and celluar immnunity in COVID-19 convalescent individuals.(Report) (2020) Immunity. 52:971-977.

15.Chang, D., Xing, Q., Su, Y., Zhao, X., Xu, W., Wang, X. andDong, C.The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation. (2020) Immunity. 53:614-626.

16.Huang, J., Lee, H. Y., Zhao, X., Han, J., Su, Y., Sun, Q., Shao, J., Ge, J., Zhao, Y., Bai, X., He, Y., Wang, X., Wang, X. andDong, C.Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93. (2021) Immunity 54:673-686.

17.Sun, L., Zhao, X., Liu, X., Zhong, B., Tang, H., Jin, W., Clevers, H., Wang, H., Wang, X. andDong, C.Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription. (2021) Cell Reports. 35:109188.