Mucosal immunology
The gut mucosal immune system not only protects us from numerous pathogen invasion, but also maintains the homeostasis with commensal bacteria and innocuous food antigens. The failure of gut homeostasis not only increases the risk of gut infection, inflammatory bowel disease, but is also related to allergy, cancer, autoimmune, and metabolic diseases. Our lab’s goal is to combine molecular data with in vivo models to further the understanding of mechanisms underlying these homeostatic and pathological conditions and aid in the development of treatments for these gut related diseases
1. The development of innate lymphoid cells and gut associated lymphoid tissues.
2. The function of innate lymphoid cells in gut related diseases.
3. The interaction between innate lymphoid cells, other immune cells and microbiota for gut homeostasis.
4. Mucosal vaccine and oral tolerance.
1.Yao He, Liuhui Fu, Yiping Li, Wenyan Wang, Mingli Gong, Jing Zhang, Xin Dong, Jiaoyan Huang, Quanbo Wang, Charles R. Mackay, Yang-Xin Fu, Yun Chen, Xiaohuan Guo. Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity. Cell Metabolism. (2021) 33, 988–1000
2.Wenyan Wang, Yan Xing, Yanmei Chang, Ying Wang, Yanxia You, Zekun Chen, Defu Ma, Xiaomei Tong, Xiaohuan Guo. The Impaired Development of Innate Lymphoid Cells by Preterm Birth Is Associated with the Infant Disease. Science bulletin. (2020) 66,421–424
3.Wenyan Wang, Yiping Li, Jiacheng Hao, Yao He, Xin Dong, Yang-Xin Fu, Xiaohuan Guo. The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the mLN Restrains Intestinal Humoral Immunity. Cell Reports. (2020) 32, 107936
4.Xiaohuan Guo, Yang-Xin Fu. The tragic fate of group 3 innate lymphoid cells during HIV-1 infection. J Clin Invest (2015) 125(9):3430-2
5.Xiaohuan Guo, Yong Liang, Yuan Zhang, Anna Lasorella, Barbara L. Kee, Yang-Xin Fu. Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2−Dependent Regulation of Microbiota. Immunity (2015) 42(1): 731–743
6.Xiaohuan Guo, Ju Qiu, Tony Tu, Xuanming Yang, Liufu Deng, Robert A. Anders, Liang Zhou, and Yang-Xin Fu. Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection. Immunity (2014) 40(1): 25–39
7.Xiaohuan Guo, Yanfei Zhang, Pingzhang Wang, Ting Li, Weiwei Fu, Xiaoning Mo, Taiping Shi, Zhixin Zhang, Yingyu Chen, Dalong Ma, Wenling Han. VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells. Cellular Immunology (2012) 278(1-2):136-42
