Dr. Yinqing Li's research focuses on the molecular and cellular changes that drive the onset and progression of complex diseases. The crucial aspect of his approach is to discern which molecules and cells undergo pivotal changes at specific time points during disease development, and to determine how these changes affect cellular functionality and interactions. This understanding is critical for developing effective diagnostic and therapeutic strategies, including targeting and modifying these essential molecules and cells to manage diseases.

His main research efforts are categorized into three primary areas:

Single-cell Characterization Technologies: Developing single-cell multi-omics techniques to capture dynamic changes in the epigenome, transcriptome, and signaling pathways. These methods allow for analysis at very rapid temporal and precise spatial scales, providing a detailed view of molecular and cellular interactions.

Gene Editing Technologies: Exploring novel gene editing systems for accurate gene replacement and epigenetic control, enabling holistic regulation of cellular states at the genetic level.

Bioinformatics: Advancing and applying statistical inference and machine learning algorithms to analyze high-throughput data in depth, discovering new genomic phenomena and modalities.