1. 氮杂环卡宾有机不对称催化对醛实现多位点、选择性的官能化：以廉价易得的醛为基础化工原料，实现多位点、选择性的官能化是构筑新颖手性片段最直接、高效的方法之一。同时这些片段是各种高附加值化学产品或药物的前体，具有重要的商业价值。申请人通过改造卡宾催化剂立体结构和电子效应来调控反应的化学、区域、以及立体选择性；通过引入协同催化策略和发展合适的亲电或亲核试剂来优化反应的活化能,最终在醛的多个位置(邻位、间位、远端的碳)实现了不对称氟化、氢酰化、中环化、芳构化等官能团化反应。重点突破了对富电子烯烃加成难得瓶颈,填补了卡宾高效、多样性催化合成光学活性寡糖得空白; 发展了卡宾与路易斯酸或布朗斯特酸催化协同策略，为“卡宾催化实现远程立体控制”提供了解决思

路。

2. 金属参与的碳氢键催化活化实现杂环的高效合成：提出了基于金属插入碳氢键活化的方式，结合炔作为搭建砌块，高区域选择性的合成了一些重要的杂环骨架，为多样性合成基于该类优势核心结构的先导化合物或杂环碎片提供了重要方法依据。

3. 通过高通量筛选，并对所发现的先导化合物进行改造，成功了发现了能够诱导胚胎干细胞定向分化和控制造血干细胞体外扩增的Lead小分子。该两个项目已经分别进入了不同的临床实验阶段，将对干细胞再生药物的研究起到重要推动作用。

4．基于“遗忘机制”开发治疗老年痴呆症新药：申请人团队与清华大学生命学院脑科学专家钟毅教授团队联合，结合多年对研究大脑所获得的深入理解，另辟蹊径，以遗忘机制作为研发老年痴呆症疾病的全新突破口，通过确定遗忘分子，来开发抑制加速遗忘的药物，以期从记忆层面来改善老年痴呆疾病的新药。目前老年痴呆（AD）新药开发（first-in-class类）获得CDE审批,已经在宣武,协和等医院开展临床研究。

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