贾怡昌博士，完美体育·(中国)官方网站长聘教授，北大-清华生命科学联合中心，清华-IDG麦戈文脑科学联合研究院，清华大学脑与智能实验室研究员。主要从事神经元存活和神经退行性疾病发病机制的研究。2006年在中科院神经科学研究所获得博士学位，师从王以政院士。2007年，加入美国小鼠遗传圣地杰克逊研究所Dr. Susan Ackerman（美国科学院院士）实验室，利用小鼠遗传学研究神经退行性疾病的发病机制。2012年获得了美国健康研究院颁发的独立科学研究人奖（K99/R00, pathway to independent award），2013年入选中国国家人才计划。以第一作者和通讯作者身份在《Nature》、《Nature Neuroscience》、《Cell》、《Brain》、《Protein & Cell》、《Molecular Psychiatry》和《Cell Research》等国际知名学术期刊发表学术文章。贾怡昌教授的实验室重要关注：（1）RNA代谢异常和内质网稳态失调引起的神经退行性和神经发育障碍的疾病机制；（2）哺乳动物语音的分子机制及其在神经发育疾病中的作用；（3）建立新的神经系统疾病的细胞和动物模型。

1. Disruption of ER ion homeostasis maintained by an ER anion channel leads to ALS-like pathology. Liang Guo, Qionglei Mao, Ji He, Xiaoling Liu, Xuejiao Piao, Li Luo, Xiaoxu Hao, Bailong Xiao, Dongsheng Fan, Zhaobing Gao, and Yichang Jia. Cell Research. 2023 May 04. doi:10.1038/s41422-023-00798-z. PMID: 37142673.

2. A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration. Dawei Meng, Qian Zheng, Xue Zhang, Li Luo, and Yichang Jia. Protein & Cell. 2023 May 08;14(5):318-336. PMID: 37027487.

3. TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain. Huihui Qi, Li Luo, Caijing Lu, Runze Chen, Xiaohui Zhang, and Yichang Jia. Molecular Psychiatry. 2023 Feb 13. doi: 10.1038/s41380-023-01993-5. PMID: 36782064.

4. Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo. Xuejiao Piao, Dawei Meng, Xue Zhang, Qiang Song, Hailong Lv, and Yichang Jia. Sci Rep. 2022 Apr 5;12(1):5672. doi: 10.1038/s41598-022-07746-8. PMID: 35383205.

5. In vivo stress granule misprocessing evidenced in a FUS knock-in ALS mouse model. Zhang X, Wang F, Hu Y, Chen R, Meng D, Guo L, Lv H, Guan J, Jia Y. Brain. 2020 May 1. doi: 10.1093/brain/awaa076. PMID: 32358598.

6. An ENU-induced mutation in Twist1 transactivation domain causes hindlimb polydactyly with complete penetrance and dominant-negatively impairs E2A-dependent transcription. Chen RZ, Cheng X, Tan Y, Chang TC, Lv H, Jia Y. Sci Rep. 2020 Feb 12;10(1):2501. doi: 10.1038/s41598-020-59455-9. PMID: 32051525.

7. Loss of Clcc1 results in ER stress, misfolded protein accumulation, and neurodegeneration. Jia Y, Jucius TJ, Cook SA, Ackerman SL. J Neurosci. 2015 Feb 18;35(7):3001-9. doi: 10.1523/JNEUROSCI.3678-14.2015. PMID: 25698737.

8. Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration. Jia Y, Mu JC, Ackerman SL. Cell. 2012 Jan 20;148(1-2):296-308. doi: 10.1016/j.cell.2011.11.057. PMID: 22265417.

9. TRPC channels promote cerebellar granule neuron survival. Jia Y, Zhou J, Tai Y, Wang Y. Nat Neurosci. 2007 May;10(5):559-67. PMID: 17396124.

10. Critical role of TRPC6 channels in the formation of excitatory synapses. Zhou J, Du W, Zhou K, Tai Y, Yao H, Jia Y, Ding Y, Wang Y. Nat Neurosci. 2008 Jul;11(7):741-3. doi: 10.1038/nn.2127. PMID:18516035.

11. Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Li Y, Jia YC, Cui K, Li N, Zheng ZY, Wang YZ, Yuan XB. Nature. 2005 Apr 14;434(7035):894-8. PMID: 15758952.

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