精准微创诊疗与三维影像领域的原始创新、技术突破与医工交叉转化

廖洪恩教授专注于三维影像与医学可视化研究，开拓了三维空间信息引导直观可视的微创诊疗新领域。在精准微创诊疗与三维医学影像领域的科学探索、关键技术和“产学研医”转化领域获得了具有重要科学意义和应用价值的成果。研究融合信息学、光学、医学等跨学科领域，为复杂精准医学中如何通过优化三维视觉效能提升医生的认知力、判断力与执行力提供了独创性思路，实现了多项基础原理与重大科学问题的突破，并积极探索未来颠覆性的真三维成像与显示技术，处于此领域科学研究前沿。

1.真三维立体成像领域研究、开创长距离立体显示新理论

廖洪恩教授团队是国际上最早实现全真彩色、无偏差与视觉疲劳、可实时交互的裸眼立体显示的团队之一，也是最早开展精准医用三维显示器领域研究的学者。在真三维可视化领域系统开展了高清、高速、超长距离显示系列创新性基础研究，在长距离立体显示领域中首次研制出裸眼可视的图像纵深5米以上的超长距离系统，实现了世界最长距离的立体显示,获中、美、欧洲和日本15项发明专利。

2.空间透视融合微创诊疗导航理论与关键技术研究

廖洪恩教授在医工交叉前沿领域实现了高精度、动态可交互、精准直观的，可从体外获得手术中病灶部位三维构造的微创手术立体空间透视导航，突破了困扰医生多年的“眼手协调”瓶颈，为观察者提供了新的“眼”。研究成果相继获我国生物医学工程学科最高科技奖“黄家驷生物医学工程奖”，第11届北京发明创新大赛金奖，以及多项国际学术会议奖项。2020年3月，应《人民日报》邀请刊登最新科研成果。

3.智能诊疗一体化系统的应用论证与临床转化

廖洪恩教授进行了智能精准诊疗由概念·研究·临床应用的转化。独创的空间立体融合导航装置和智能微创诊断治疗一体化系统在北京天坛医院、北京清华长庚医院、日本东京大学附属医院等国内外医疗机构中开展多领域的临床试验评估，在神经外科、骨科、肝胆复杂病变等诊疗中均与现有商业系统相比均具明显优势，为推动国产高端医疗设备发展做出贡献。系列成果被美国、英国、德国、俄罗斯、日本等国际媒体广泛深入报道，并在德国汉诺威世界博览会、日本科学未来馆、中国科学技术馆等十几家展览会和博物馆展出。

Innovative techniques and applications of precision minimally invasive theranostics

Prof. Hongen Liao focuses on the interdisciplinary field ofrealthree-dimensional (3D) image processing and medical visualization with domestic and international research career of more than twenty years, pioneered a frontier research area of intuitive spatial 3D image-guide precision minimally invasive diagnosis and therapy.He has obtained scientifically significant and applied results in the field of scientific exploration, key technologies and " academia-research-industry " transformation in the field of minimally invasive treatment and 3D stereoscopic display, and integrated diagnostic and therapeutic techniques for intelligent medicine. The research integrates the interdisciplinary fields of informatics, optics and medicine, and provides original ideas on how to improve the cognitive ability, judgment and execution of doctors in complexandprecisionoperationsby optimizing the effectiveness of 3D vision, and achieves breakthroughs in many fundamental principles and major scientific problems, and actively explores future real 3D imaging and display technologies, which is at the forefront of scientific research in this field.

1. Real 3D medical imaging and the new theory of long-distance 3D display

Prof. Liao's team is one of the first teams in the world to realize naked-eye 3D display with full true color, no visual fatigue, and real-time interaction.Dr. Liao focused on the field of autostereoscopic 3D imaging and medical autostereoscopic display for more than twenty years, pioneered a frontier research area of intuitive spatial 3D image-guide precision minimally invasive diagnosis and therapy. He has developed the first super-long viewing distancedisplaysystem with an image depth of more than six meters visible to the naked eye, achieving the longest stereo display in the world. He has been awardedmorethan15 invention patents in the United States, Europe, Japan and China in this field.

2. Minimally invasive surgical navigation using 3Dimageoverlay

Prof. Liao has achieved a high-precision, dynamic, interactive, precise and intuitive minimally invasive surgical 3D image overlay navigation that can obtain the spatial structure of the surgical targets from outside of the body, breaking the bottleneck of "eye-hand coordination" that suffered by doctors and providing a new "eye" for the observer. The research has been awarded several international and domestic awards. In March 2020, he was invited by the People's Daily to publish his latest research achievements.

3. Development and application oftheintegrated diagnostic and therapeutic system for intelligent medicine

Professor Liao has carried out the transformation of intelligentprecisiondiagnosis and therapy from concept - research - clinical application. The original spatial three-dimensional fusion navigation deviceandintegrated intelligent diagnostic and therapeutic system have been evaluated in clinical trials in many fields in domestic and foreign medical institutions such as Beijing Tiantan Hospital, Beijing Tsinghua Changgung Hospital, The University of Tokyo Hospital, etc. It hasshownadvantages over existing commercial systems in the diagnosis and treatment of neurosurgery, orthopedics, and complex hepatobiliary lesions, and has contributed to the promotion of the development of domestic high-end medical equipment. The series of achievementsabovehave been widely reported by international media such as USA, UK, Germany, Russia and Japan, and exhibited in several famous exhibitions and museums such as Hannover World Fair in Germany, Science Future Museum in Japan and China Science and Technology Museum,etc.

廖洪恩教授在包括IEEE Trans系列、Nature Photonics、Theranostics、MedIA等发表了300余篇国际期刊和学会论文、30余篇综述文章、320余篇会议摘要，合编著书籍13部，近年来代表性论著如下：

1.J. Zhang#, D. Sun#, Z. Luo, A. Yao, H. Chen, L. Zhou, T. Shen, Y. Chen, L. Quan, and H. Liao*: Learning Two-View Correspondences and Geometry Using Order-Aware Network, IEEE Transactions on Pattern Analysis and Machine Intelligence, 2021. (in press, DOI: 10.1109/TPAMI.2020.3048013)

2.G. Ning, X. Zhang, Q. Zhang, Z. Wang and H. Liao*: Real-time and multimodality image-guided intelligent HIFU therapy for uterine fibroid, Theranostics, Vol. 10, No. 10, pp. 4676-4693, 2020. (FrontCover Article)

3.C. Ma, G. Chen, X. Zhang, G. Ning, H. Liao*: Moving-Tolerant Augmented Reality Surgical Navigation System Using Autostereoscopic Three-Dimensional Image Overlay, IEEE Journal of Biomedical and Health Informatics, Vol. 23, No. 6, pp. 2483-2493, 2019. (Cover Article)

4.B. Zhang, F. Ying, P. Yang, T. Cao, and H. Liao*: Worm-like Soft Robot for Complicated Tubular Environments, Soft Robotics, Vol. 6, No. 3, pp. 399-413, 2019.

5.F. Chen#, Z. Zhao#, C. Gao, J. Liu, X. Su, J. Zhao, P. Tang*, H. Liao*: Clustering of Morphological Features for Identifying Femur Cavity Subtypes with Difficulties of Intramedullary Nail Implantation, IEEE Journal of Biomedical and Health Informatics, Vol. 22, No. 4, pp.1209-1217, 2018.

6.Y. Fan#, Y. Sun#, W. Chang, X. Zhang, J. Tang, L. Zhang*, H. Liao*: Bioluminescence imaging and two-photon microscopy guided laser ablation of GBM decreases tumor burden, Theranostics, Vol. 8, No. 15, pp.4072-4085, 2018. (FrontCover Article)

7.G. Chen, C. Ma, M. Liu, Z. Fan, X. Cui, H. Liao*: Real Time Lens based Rendering Algorithm for Super-multiview Integral Videography without Pixel Resampling, IEEE Transactions on Visualization and Computer Graphics, Vol.24, No.9, pp.2600-2609, 2018.

8.F. Chen, J. Liu, and H. Liao*: 3D Catheter Shape Determination for Endovascular Navigation using a Two-step Particle Filter and Ultrasound Scanning, IEEE Transactions on Medical Imaging, Vol. 36, No.3, pp.685-695, 2017.

9.X. Zhang, G. Chen, and H. Liao*: High Quality See-Through Surgical Guidance System Using Enhanced 3D Autostereoscopic Augmented Reality, IEEE Transactions on Biomedical Engineering, Vol. 64, No. 8, pp.1815-1825, Aug. 2017.

10.Z. Fan, S. Zhang, Y. Weng, G. Chen, H. Liao*: 3D Quantitative Evaluation System for Autostereoscopic Display, IEEE/OSA Journal of Display Technology, Vol.12, No.10, pp.1185-1196, 2016.

11.H. Liao*: Super long viewing distance light homogeneous emitting three-dimensional display, Scientific Reports, 5: 9532, 2015.

12.J. Wang, H. Suenaga, K. Hoshi, L. Yang, E. Kobayashi, I. Sakuma, and H. Liao*: Augmented Reality Navigation with Automatic Marker-Free Image Registration Using 3-D Image Overlay for Dental Surgery, IEEE Transactions on Biomedical Engineering, Vol.61, No.4, pp.1295-1303, 2014.

13.K. Nakagawa, A. Iwasaki, Y. Oishi, R. Horisaki, A. Tsukamoto, A. Nakamura, K. Hirosawa, H. Liao, T. Ushida, K. Goda, F. Kannari, and I. Sakuma: Sequentially timed all-optical mapping photography (STAMP), Nature Photonics, Vol.8, No.9, pp.695–700, 2014.

14.H. Liao*: Integrated diagnostic and therapeutic techniques: Toward an intelligent medical system, Computerized Medical Imaging and Graphics, Vol. 38, No.5, pp.421-422, 2014.

15.H. Liao*, M. Noguchi, T. Maruyama, Y. Muragaki, E. Kobayashi, H. Iseki, I. Sakuma: An Integrated Diagnosis and Therapeutic System using Intraoperative 5-Aminolevulinic-Acid-Induced Fluorescence Guided Robotic Laser Ablation for Precision Neurosurgery, Medical Image Analysis, Vol.16, No. 3, pp.754-766, 2012.

16.H. Liao*, T. Inomata, I. Sakuma, and T. Dohi: Three-dimensional Augmented Reality for MRI-guided Surgery using Integral Videography Autostereoscopic-image Overlay, IEEE Transactions on Biomedical Engineering, Vol.57, No.6, pp.1476-1486, 2010. (Cover Article)

17.H. Liao*, M. Iwahara, Y. Katayama, N. Hata, T. Dohi: Three-dimensional display with a long viewing distance by use of Integral Photography, Optics Letter, Vol. 30 No. 6, pp. 613-615, March 2005.

18.H. Liao*, M. Iwahara, N. Hata, T. Dohi: High-quality integral videography using a multiprojector, Optics Express, Vol. 12 No. 6, pp. 1067-1076, 2004.

(更多论文等科研成果请访问http://at3d.med.tsinghua.edu.cn/publications/index.html)

学术荣誉与奖励

廖洪恩教授曾获国际医学生物工程联合会颁发的IFMBE青年学者奖（IFMBE Young Investigators Award）、日本政府颁发的文部科学大臣青年科学家奖、船井信息科学奖（Funai Information Science Award）、爱立信青年科学家奖（ERICSSON Young Scientist Award）等十余项国际/地区性重要奖项。2017年获得我国生物医学工程学科最高科技奖“黄家驷生物医学工程奖”，2018年获“中国侨界贡献奖”一等奖，以及国务院侨办颁发的“全国归侨侨眷先进个人”，2019年被中国科协聘任为首席科学传播专家，2020年获中国致公党中央委员会“致公党抗击新冠肺炎疫情先进个人”称号，2021年获SID北京分会杰出贡献奖。

Honors and Awards

Dr. Liao was distinguished by receiving the Government Award [The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (MEXT), Japan] (2006). He was also the recipient of more than ten awards, including the ERICSSON Young Scientist Award (2006), the IFMBE Young Investigators Awards presented by the World Congress on Medical Physics and Biomedical Engineering (2006) and the 6th Asian-Pacific Conference on Medical and Biological Engineering (2005), the FUNAI Information Science Award (2005), and various Best Paper Awards (CARS 2013, JSCAS 2012, ACCAS 2010, JSCAS 2009) from different academic societies. He won the "Huang Jiasi Biomedical Engineering Award", which is the highest science and technology award in the field of Biomedical Engineering in 2017. In 2018, he won the First Prize of “Overseas Chinese Contribution Award” and received the “National Advanced Individuals of Returned Overseas Chinese” issued by the Overseas Chinese Affairs Office of The State Council. In 2019, he was appointed as a Chief Science Communication Expert by the Chinese Association for Science and Technology. In 2021, he received the “SID Beijing Chapter Outstanding Contribution Award”.

开设课程

数字化医学与微创诊疗原理

生物医学工程前沿动态讲座

Courses

Digital Medicine and Minimally Invasive Surgery

Frontiers of Biomedical Engineering Seminar

社会职务

廖洪恩教授现任中国科协全国首席科学传播专家、中国生物医学工程学会常务理事，国家食品药品监督管理总局医疗器械分类技术委员会专业组委员等。担任过MIAR, MICCAI, ACCAS等近十个国际会议的大会主席、程序委员会主席、组委会主席，以及20几个国际杂志和会议论文集的副编辑、编委和特邀审查员。受邀担任瑞士、荷兰、加拿大、日本、新加坡等国家多个科研基金评审委员会委员和评审员，以及国家自然科学基金、“长江学者奖励计划”（讲座教授、特聘教授、青年长江、特设岗位）、国家海外高层次人才引进计划（创新、创业、青年、外专），国家高层次人才特殊支持计划（“万人计划”）、国家食药监总局创新医疗器械等评审专家、专家组组长。在国际组织中任国际医学生物工程联合会亚太区联席主席、亚洲计算机辅助外科学会理事长等职务。

Social Service

He is a Chief Science Communication Expert by the Chinese Association for Science and Technology, executive director of the Chinese Society of Biomedical Engineering, and member of the professional group of the Technical Committee of Medical Device Classification of the State Food and Drug Administration. He is also an Associate Editor of International Conference of IEEE Engineering in Medicine and Biology Society (Since 2008), the Organization Chair of Medical Imaging and Augmented Reality Conference (MIAR) 2008, the Program Chair of the Asian Conference on Computer-Aided Surgery (ACCAS) 2008 and 2009, the Tutorial co-chair of the Medical Image Computing and Computer Assisted Intervention Conference (MICCAI) 2009, the Publicity Chair of MICCAI 2010, the General Chair of MIAR 2010 and ACCAS 2012, the Workshop Chair of MICCAI 2013, and the General Co-chair of MIAR 2016, ACCAS 2018. He has served as a President of Asian Society for Computer Aided Surgery and Co-chair of Asian-Pacific Activities Working Group, International Federation for Medical and Biological Engineering (IFMBE).

技术专利

1.三维位姿检测装置及方法，授权发明专利，ZL 201910194763.7，授权公告日2021-1-29；

2.一种外骨骼康复系统及康复方法，授权发明专利，ZL 201910183301.5，授权公告日2020-3-20；

3.基于光相干断层成像的共光路智能光学诊疗系统，授权发明专利，ZL 201910123178.8，授权公告日2020-10-16；

4.复合信息真三维显示方法及系统，授权发明专利，ZL 201910035914.4，授权公告日2020-9-29；

5.用于外科手术的智能成像系统，授权发明专利，ZL 201610080180.8，授权公告日2018-11-9；

6.一种自投影式内窥镜装置，授权发明专利，ZL 201810629488.2，授权公告日2020-7-21；

7.多源信息引导激光消融的诊疗方法及系统，授权发明专利，ZL 201810675326.2，授权公告日2020-6-12；

8.一种增强现实操作方法及系统，授权发明专利，ZL 201710059001.7，授权公告日2019-6-18；

9.一种长距离裸眼三维显示方法及系统，授权发明专利，ZL201710575842.3，授权公告日2019-3-1；

10.基于虚拟标志物的三维空间定位追踪方法及系统，授权发明专利，ZL 201410200222.8，授权公告日2016-12-7。

Patents

Prof. Liao has over 50 patents in the field of advanced theranostics and 3D medical imaging.