1. F. Wu, P. M. Chen, T. C. Gardinier, M. Z. Turker, A. M. Venkatesan, V. Patel, T. Khor, M. S. Bradbury, U. B. Wiesner, G. P. Adams, G. Germano, F. Chen*, and K. Ma*, Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer,ACS Nano16, 20021-20033 (2022).
2. T. Aubert#, K. Ma#, K. Tan, U. Wiesner*, Two-Dimensional Superstructures of Silica Cages,Advanced Materials32, 1908362 (2020).
3. F. Chen#, B. Madajewski#, K. Ma#, D. K. Zanoni, H. Stambuk, M. Pauliah, M. Z. Turker, S. Monette, L. Zhang, B. Yoo, P. Chen, R. J. C. Meester, S. D. Jonge, T. P. Quinn, M. Gonen, S. Sequeira, E. D. Stanchina, J. D. Wolchok, P. Zanzonico, U. Wiesner*, S. G. Patel*, M. S. Bradbury*, Molecular Phenotyping and Image-Guided Surgical Treatment of Melanoma Using Spectrally-distinct Ultrasmall Core-Shell Silica Nanoparticles,Science Advances, 5, 12 (2019), doi:10.1126/sciadv.aax5208.
4. K. Ma, Y. Gong, T. Aubert, M. Turker, T. Kao, P. Doerschuk, U. Wiesner*, Surfactant Micelle Self-assembly Directed Highly Symmetric Ultrasmall Inorganic Cages,Nature558, 577–580 (2018).
5. F. Chen#, K. Ma#, B. Madajewski, L. Zhuang, L. Zhang, K. Rickert, M. Marelli, B. Yoo, M. Turker, M. Overholtzer, T. Quinn, M. Gonen, P. Zanzonico, A. Tuesca, M. Bowen, L. Norton, J. Subramony, U. Wiesner*, M. Bradbury*, Ultrasmall Targeted Nanoparticles with Engineered Antibody Fragments for Imaging Detection of HER2-overexpressing Breast Cancer,Nature Communications9, 4141 (2018).
6. K. Ma, K. A. Spoth, Y. Cong, D. Zhang, T. Aubert, M. Z. Turker, L. F. Kourkoutis, E. Mendes, U. Wiesner*, Early Formation Pathways of Surfactant Micelle Directed Ultrasmall Silica Ring and Cage Structures,J. Am. Chem. Soc.140, 17343–17348 (2018).
7. Y. Sun#, K. Ma#, T. Kao#, K. A. Spoth, H. Sai, D. Zhang, L. F. Kourkoutis, V. Elser, U. Wiesner*, Formation Pathways of Mesoporous Silica Nanoparticles with Dodecagonal Tiling,Nature Communications8, 252 (2017).
8. S. E. Kim, L. Zhang, K. Ma, M. Riegman, F. Chen, I. Ingold, M. Conrad, M. Z. Turker, M. Gao, X. Jiang, S. Monette, M. Pauliah, M. Gonen, P. Zanzonico, T. Quinn, U. Wiesner, M. S. Bradbury*, M. Overholtzer*, Ultrasmall Nanoparticles Induce Ferroptosis in Nutrient-Deprived Cancer Cells and Suppress Tumour Growth,Nature Nanotechnology11, 977–985 (2016).
专利技术
截至2022年,马恺教授获得国内外已授权发明专利30余项,其中24项已成果转化,部分专利列举如下:
1. Functionalized nanoparticles and methods of making and using same, United States Patent US11419952B2, K. Ma, U. Wiesner
2. Ultrasmall nanoparticles and methods of making and using same, United States Patent US11291737B2, U. Wiesner, K. Ma, C. Mendoza
3. Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis, United States Patent US11246946B2, M. Bradbury, U. Wiesner, M. Overholtzer, H. Scher, K. Ma
4. Nanoparticle drug conjugates, Chinese Patent CN106659797B, B. Yoo, M. Bradbury, U. Wiesner, K. Ma
5. Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging, United States Patent US10940216, M. Bradbury, B. Yoo, U. Wiesner, P. Chen, K. Ma, S. Patel, D. K. Zanoni
6. Mesoporous oxide nanoparticles and methods of making and using same, United States Patent US10732115, U. Wiesner, K. Ma
7. Nanoparticle immunoconjugates, United States Patent US20180133342A1, B. Yoo, T. Quinn, M. Bradbury, U. Wiesner, J. Lewis, K. Ma, Feng Chen