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刘冉

结合生物材料与微纳米技术,建立微系统技术与生物医学应用之间的桥梁和接口

E-mail: liuran@tsinghua.edu.cn

  • 科研领域及主要成果

  • 代表性论著

研发基于生物混合界面的人体集成柔性器件,发展具有更好生物兼容特性的医学微系统

刘冉的科研重点是微纳米系统设计和工艺研究,研究方向聚焦在医学微系统技术,致力于寻求微纳米技术与生物医学应用之间的桥梁,通过生物材料与微纳米技术的结合,进行基于生物混合界面的人体集成柔性器件的研发,发展具有更好生物兼容特性的医学微系统,并由此延伸开发独特的微加工方法及生物接口技术。

她已经成功实现了柔性和微阵列电极、刚柔复合药物递送微系统、可降解编码载药微芯片等技术,具体研究成果包括提出一种全新的折叠式双面导通柔性电极设计、创新性设计金字塔形叠层丝素蛋白全降解微针可控药物递送微系统、首次制备基于温敏生物材料的全降解式可控瞬态电子器件、构建复合弹性模量的柔性混合电路设备。

1.X. Li, X. Xu, K. Wang, Y. Chen, Y. Zhang, Q. Si, Z. Pan, F. Jia, X. Cui, X. Wang, X. Deng, Y. Zhao, D. Shu, Q. Jiang,* B. Ding,* Y.Wu,* R. Liu*, Fluorescence-Amplified Origami Microneedle Device for Quantitatively Monitoring Blood Glucose. Adv Mater. 2023, 35(29), e2208820. ( Frontispiece)

2.W. Zhou, R. Lin, H. Li, R. Liu, Nano foldaway skin-like e-interface for detecting human bioelectrical signals, ACS Appl. Mater. Interfaces. 2021, 13, 148–154.

3.Y. Yan, B. Zhang, Q. Fu, J. Wu, R. Liu, A fully integrated biomimetic microfluidic device for evaluation of sperm response to thermotaxis and chemotaxis, Lab Chip, 2020, 21, 310-318. (Back Cover)

4.R. Lin, Y. Li, X. Mao, W. Zhou, R. Liu, Hybrid 3D printing all‐in‐one heterogenous rigidity assemblies for soft electronics, Adv. Mater. Technol. 2019, 4, 1900614. (Inside Front Cover)

5.R. Lin, X. Yan, H. Hao, W. Gao, R. Liu, Introducing temperature-controlled phase transition elastin-like polypeptides to transient electronics: realization of proactive biotriggered electronics with local transience, ACS Appl. Mater. Interfaces. 2019, 11, 46490–46496.

6.S. Guo, R. Lin, L. Wang, S. Lau, Q. Wang, R. Liu, Low melting point metal-based flexible 3D biomedical microelectrode array by phase transition method, Mater. Sci. Eng. C, 2019, 99, 735–739.

7.S. Lau, J. Fei, H. Liu, W. Chen, R. Liu, Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery, J. Control. Release, 2017, 265, 113–119.