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Dec 13, 2017
Hang YIN publishes"Small-molecule inhibition of TLR8 through stabilization of its resting state" in Nature Chemical Biology

Endosomal Toll-like receptors (TLR3, TLR7, TLR8, and TLR9) are highly analogous sensors for various viral or bacterial RNA and DNA molecular patterns. Nonetheless, few small molecules can selectively ...
Nov 29, 2017
Yefeng TANG publishes "Enantioselective and Collective Total Syntheses of Xanthanolides" in Angew. Chem. Int. Ed.

An enantioselective synthesis of (+)-8-epi-xanthatin hinging on a chiral phosphoric acid catalyzed tandem allylboration/lactonization reaction is reported. With (+)-8-epi-xanthatin as the precursor, t...
Nov 27, 2017
Bailong XIAO publishes"A protein interaction mechanism for suppressing the mechanosensitive Piezo channels" in Nature Communications

Piezo proteins are bona fide mammalian mechanotransduction channels for various cell types including endothelial cells. The mouse Piezo1 of 2547 residues forms a three-bladed, propeller-like homo-trim...
Sep 19, 2017
Ligong CHEN publishes"A Network Integration Approach for Drug-Target Interaction Prediction and Computational Drug Repositioning from Heterogeneous Information

The emergence of large-scale genomic, chemical and pharmacological data provides new opportunities for drug discovery and repositioning. In this work, we develop a computational pipeline, called DTINe...
Sep 05, 2017
Ligong CHEN publishes"Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity" in Archives of Toxicology

Zoledronate is a bisphosphonate that is widely used in the treatment of metabolic bone diseases. However, zoledronate induces significant nephrotoxicity associated with acute tubular necrosis and rena...
Aug 20, 2017
Xuebin LIAO research group publishes “In situ generation of N-unsubstituted imines from alkyl azides & applications for imine transfer” in Science Advances

Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated for...
Jun 30, 2017
Liansuo Zu research group publishes “ Catalytic Enantioselective Aza-pinacol Rearrangement” in Angew. Chem. Int. Ed.

The first catalytic enantioselective asymmetric aza-pinacol rearrangement is reported. The reactions are catalyzed by a chiral phosphoric acid and proceed via a highly organized transition state invol...
May 18, 2017
Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. Chem. Int. Ed.

We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series of ra...
Apr 29, 2017
Ligong CHEN research group discovers the mechanism process of renal toxicity induced by adefovir and tenofovir

Despite the therapeutic success of tenofovir (TFV) for treatment of HIV-1 infection, numerous cases of nephrotoxicity have been reported. Mitochondrial toxicity has been purported as the major target ...
Apr 29, 2017
Ligong CHEN publishes “A "functional signaling indispensable is for c-Myc driven hepatocarcinogenesis" in Hepatology

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events leading to hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally by the ...

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School of Pharmaceutical Sciences

School of Pharmaceutical Sciences

Hang YIN publishes"Small-molecule inhibition of TLR8 through stabilization of its resting state" in Nature Chemical Biology

Endosomal Toll-like receptors (TLR3, TLR7, TLR8, and TLR9) are highly analogous sensors for various viral or bacterial RNA and DNA molecular patterns. Nonetheless, few small molecules can selectively ...

Yefeng TANG publishes "Enantioselective and Collective Total Syntheses of Xanthanolides" in Angew. Chem. Int. Ed.

An enantioselective synthesis of (+)-8-epi-xanthatin hinging on a chiral phosphoric acid catalyzed tandem allylboration/lactonization reaction is reported. With (+)-8-epi-xanthatin as the precursor, t...

Bailong XIAO publishes"A protein interaction mechanism for suppressing the mechanosensitive Piezo channels" in Nature Communications

Piezo proteins are bona fide mammalian mechanotransduction channels for various cell types including endothelial cells. The mouse Piezo1 of 2547 residues forms a three-bladed, propeller-like homo-trim...

Ligong CHEN publishes"A Network Integration Approach for Drug-Target Interaction Prediction and Computational Drug Repositioning from Heterogeneous Information

The emergence of large-scale genomic, chemical and pharmacological data provides new opportunities for drug discovery and repositioning. In this work, we develop a computational pipeline, called DTINe...

Ligong CHEN publishes"Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity" in Archives of Toxicology

Zoledronate is a bisphosphonate that is widely used in the treatment of metabolic bone diseases. However, zoledronate induces significant nephrotoxicity associated with acute tubular necrosis and rena...

Xuebin LIAO research group publishes “In situ generation of N-unsubstituted imines from alkyl azides & applications for imine transfer” in Science Advances

Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated for...

Liansuo Zu research group publishes “ Catalytic Enantioselective Aza-pinacol Rearrangement” in Angew. Chem. Int. Ed.

The first catalytic enantioselective asymmetric aza-pinacol rearrangement is reported. The reactions are catalyzed by a chiral phosphoric acid and proceed via a highly organized transition state invol...

Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. Chem. Int. Ed.

We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series of ra...

Ligong CHEN research group discovers the mechanism process of renal toxicity induced by adefovir and tenofovir

Despite the therapeutic success of tenofovir (TFV) for treatment of HIV-1 infection, numerous cases of nephrotoxicity have been reported. Mitochondrial toxicity has been purported as the major target ...

Ligong CHEN publishes “A "functional signaling indispensable is for c-Myc driven hepatocarcinogenesis" in Hepatology

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events leading to hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally by the ...

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