Sep 12, 2018
Yefeng TANG and Gang LIU publish "Total Syntheses of Asperchalasines A-E" in Angew. Chem. Int. Ed.
The first total syntheses of asperchalasines A‐E, a collection of unprecedented merocytochalasans, are reported. Aspochalasin B, a key tricyclic cytochalasan monomer, was first synthesized through a unified approach that hinges on a Diels‐Alder reaction and an RCM reaction. The bioinspired Diels‐Alder reactions of aspochalasin B with different epicoccine precursors were then explored, which ...
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